Relationship between the FRAX index and physical and cognitive functioning in older people.
Ann Med. 2018 09;50(6):538-543 Authors: González Silva Y, Abad Manteca L, de la Red Gallego H, Álvarez Muñoz M, Rodríguez Carbajo M, Murcia Casado T, Ausín Pérez L, Abadía Otero J, Pérez-Castrillón JL
OBJECTIVE: To assess the relationship between the FRAX index and the Barthel index and /MiniMental State Examination in older people. PATIENTS AND METHODS: Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. RESULTS: A total of 375 patients were included (60% female) Patients with a low-risk FRAX for hip fractures had a higher Mini-mental (25, 95% CI = 24-27 vs. 22, 95% = 21 to 23, p = .0001), a higher Barthel index (88, 95% CI = 84-93 vs 72, 69 to 76, p = .0001) without differences in the Charlson index. Bivariate analysis showed an inverse association between FRAX and scales but logistic regression showed only female sex (OR 4.4, 95% CI = 2.6-7.6) and the non-dependent Barthel index (OR = 0.104, 95% CI = 0.014-0.792) remained significant and. Barthel index/Mini-mental constructed a significant model capable of predicting a risk of hip fracture of >3% measured by the FRAX index, with an area under the curve of 0.76 (95% CI = 0.7-0.81). CONCLUSIONS: The FRAX index is related to other markers of geriatric assessment and the association between these variables can predict a risk of hip fracture of >3% measured by the FRAX index. Key messages: Geriatric assessment indexes may be as important as the FRAX index, which is based on clinical risk factors, in predicting the fracture risk in older patient. PMID: 30041550 [PubMed - indexed for MEDLINE]