Risk of myocardial infarction among new users of calcium supplements alone or combined with vitamin d: a population-based case-control study.
Clin Pharmacol Ther. 2019 Sep 27;: Authors: Rodríguez-Martín S, González-Bermejo D, Rodríguez-Miguel A, Barreira D, García-Lledó A, Gil M, de Abajo FJ
A population-based case-control study was conducted to evaluate the risk of acute myocardial infarction among new users of calcium supplements, alone (CaM) or in combination with vitamin D (CaD). A total of 23025 cases and 114851 controls randomly sampled from the underlying cohort and matched with cases by age, sex and index date were included. New users of CaM and CaD were categorized as current-, recent-, past- and non-users. We computed adjusted odds ratios (AOR) and their 95%CI among current users as compared to non-users through a conditional logistic regression. No increased risk was associated with CaM overall (59 cases (0.26%) and 273 controls (0.24%); AOR=0.80;0.59-1.09), nor was it found in any of the conditions examined. Instead, the use of CaD was associated with a decreased risk (275 cases (1.19%) and 1160 controls (1.45%); AOR=0.78;0.67-0.90), dose and duration-dependent, and particularly evident in patients with a high cardiovascular risk (AOR=0.59;0.43-0.81). PMID: 31560413 [PubMed - as supplied by publisher]